Palette™ has been designed for and tested with standard nozzles (0.4 mm), but Palette and Chroma works with any size of nozzle.
While it should be possible to use with larger nozzle sizes, we consider upgrading to a high-flow nozzle an experimental activity and we do not currently guarantee the results.
The main issue we anticipate in using a high-flow nozzle is whether or not the color transitions will require a similar amount of material. High-flow nozzles may be quicker at transitioning between colors due to lower pressure and less mixing - but they might also take longer to transition due to larger hot end mixing areas. With that said, our software allows you to customize how much material your printer requires when transitioning between colors.